Document Detail


Histologic classification of penile intraepithelial neoplasia.
MedLine Citation:
PMID:  22641959     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Penile squamous cell carcinomas (SCCs) and their corresponding precancerous lesions can be classified in 2 major groups: human papillomavirus (HPV) related and HPV unrelated. In the former (warty and basaloid SCC), there is a predominance of undifferentiated basaloid cells. In the latter (eg, usual, papillary, and verrucous SCC), the predominant cell is larger with abundant eosinophilic cytoplasm. Based on these morphologic features, a new term, "penile intraepithelial neoplasia" (PeIN), was proposed. PeIN was further subclassified into differentiated and undifferentiated, with the latter being subdivided into basaloid, warty, and warty-basaloid subtypes. Macroscopically, PeIN subtypes are indistinguishable. Microscopically, differentiated PeIN is characterized by acanthosis, parakeratosis, enlarged keratinocytes with abundant "pink" cytoplasm (abnormal maturation), and hyperchromatic cells in the basal layer. In basaloid PeIN the epithelium is replaced by a monotonous population of uniform, small, round, and basophilic cells. Warty PeIN is characterized by a spiky surface, prominent atypical parakeratosis, and pleomorphic koilocytosis. Warty-basaloid PeIN show features of both warty and basaloid PeIN. There is a significant association of subtypes of PeIN with specific variants of invasive SCCs. This is a simple and reproducible nomenclature for penile precancerous lesions based on cell type and differentiation. It takes into account the similarities between vulvar and penile pathology and the hypothesis of a bimodal pathway of penile cancer progression.
Authors:
Elsa F Velazquez; Alcides Chaux; Antonio L Cubilla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in diagnostic pathology     Volume:  29     ISSN:  0740-2570     ISO Abbreviation:  Semin Diagn Pathol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502262     Medline TA:  Semin Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Affiliation:
Caris Life Sciences, Newton, Massachusetts, USA. evelazquez@carisls.com
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