Document Detail

Histologic chorioamnionitis: different histologic features at different gestational ages.
MedLine Citation:
PMID:  24047313     Owner:  NLM     Status:  Publisher    
Abstract Objective: The aim of this study was to investigate the rate of the different Histological Chorioamnionitis (HCA) grade in relation to the gestational age in term and preterm delivery. Methods: 392 women with singleton pregnancy with spontaneous onset of labor either prematurely or at term, with histologic diagnosis of HCA, were enrolled. Placentas were classified as: deciduitis and/or histologic chorioamniositis within the membranes (HCA1); amnionitis or inflammation of the chorionic plate without funisitis (HCA2) and histologic chorioamniositis with funisitis (HCA3). Microbiological culture was performed on both placental and fetal membrane samples. Results: HCA1 was more frequent in women delivering at term than in preterm (p< 0.001). HCA2 was more represented in women delivering between 32 and 36 weeks (p< 0.001) and HCA3 occurred more frequently in those delivering within 32 weeks (p< 0.001). The positive bacterial culture was higher (p=0.008) in presence of HCA3 in comparison with HCA1 and HCA2. Conclusions: The present study showed a significantly different distribution of HCA grades in relation to gestational age at delivery. HCA may represent the expression of different subtending etiologies and may also reflects specific immune competence of gestational tissues at different gestational ages, strengthening as pregnancy advances.
Michela Torricelli; Chiara Voltolini; Paolo Toti; Francesca Letizia Vellucci; Nathalie Conti; Alice Cannoni; Irene Moncini; Rossella Occhini; Filiberto Maria Severi; Felice Petraglia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-19
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Molecular and Developmental Medicine, University of Siena, Italy;
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