Document Detail

Histologic changes in the auditory tube mucosa of rats after long-term exposure to cigarette smoke.
MedLine Citation:
PMID:  19880025     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to investigate the effect of cigarette smoke on the auditory tube and middle ear mucosa after long-term exposure (4 and 6 months). MATERIALS AND METHODS: Fifteen rats were divided into 3 groups. The experimental groups were exposed to cigarette in a smoking chamber for 4 and 6 months (n = 5 each). A control group (n = 5) was placed in the same chamber without exposure to cigarette smoke. Histologic changes of the auditory tube mucosa were observed through light and electron microscopes. Histologic changes of the middle ear mucosa were also observed through light microscopes. RESULTS: The histologic changes consisted of a proliferation of goblet cells and an increase of mucus secretion in auditory tube. Squamous metaplasia was paradoxically decreased according to the duration of exposure in auditory tube. The number of goblet cell was gradually increased according to the duration of exposure in the auditory tube and middle ear. CONCLUSIONS: Long-term passive smoke directly affects the auditory tube and middle ear mucosa. Histologic changes of auditory tube mucosa consisted of goblet cell proliferation and excessive mucus secretion.
Soo-Keun Kong; Kyong-Myong Chon; Eui-Kyung Goh; Il-Woo Lee; Ji-Won Lee; Soo-Geun Wang
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Publication Detail:
Type:  Journal Article     Date:  2009-03-13
Journal Detail:
Title:  American journal of otolaryngology     Volume:  30     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-82     Citation Subset:  IM    
Department of Otorhinolaryngology Head and Neck Surgery, Pusan National University School of Medicine, Busan, Korea.
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MeSH Terms
Cell Proliferation
Environmental Exposure / adverse effects
Eustachian Tube / pathology*,  ultrastructure
Goblet Cells / pathology,  physiology*,  secretion,  ultrastructure
Mucous Membrane / pathology,  secretion,  ultrastructure
Mucus / secretion*
Random Allocation
Rats, Sprague-Dawley
Time Factors
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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