| Histologic atherosclerotic plaque characteristics are associated with restenosis rates after endarterectomy of the common and superficial femoral arteries. | |
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MedLine Citation:
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PMID: 20570468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study assessed the predictive value of histologic plaque characteristics for the occurrence of restenosis after femoral artery endarterectomy. BACKGROUND: It would be advantageous if patients at increased risk for restenosis after arterial endarterectomy could be identified by histologic characteristics of the dissected plaque. Differences in atherosclerotic plaque composition of the carotid artery have been associated with restenosis rates after surgical endarterectomy. However, whether atherosclerotic plaque characteristics are also predictive for restenosis in other vascular territories is unknown. METHODS: Atherosclerotic plaques of 217 patients who underwent a common femoral artery endarterectomy (CFAE; n = 124) or remote superficial femoral artery endarterectomy (RSFAE; n = 93) were examined and scored microscopically for the presence of collagen, macrophages, smooth muscle cells, lipid core, intraplaque hemorrhage, and calcifications. The 12-month restenosis rate was assessed using duplex ultrasound imaging (peak systolic velocity [PSV] ratio >or=2.5). RESULTS: The 1-year restenosis rate was 66% (61 of 93) after RSFAE compared to 21% (26 of 124) after CFAE. Plaque with characteristics of high collagen and smooth muscle cell content were positively associated with the occurrence of restenosis, with odds ratios (ORs) of 2.90 (95% confidence interval [CI], 1.82-4.68) and 2.20 (1.50-3.20) for superficial femoral artery (SFA) and common femoral artery (CFA), respectively. SFA plaques showed significantly heavier staining for collagen (69% vs 31% for CFA; P < .001) and smooth muscle cells (64% vs 36% for CFA; P < .001). After multivariate analysis, the operation type (CFAE or RSFAE), gender, and the presence of collagen were independent predictive variables for restenosis after endarterectomy of the CFA and SFA. CONCLUSION: Plaque composition of the CFA and SFA differs. Furthermore, the dissection of a fibrous collagen-rich plaque is an independent predictive variable for restenosis after endarterectomy of the CFA and SFA. |
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Authors:
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Wouter J M Derksen; Jean-Paul P M de Vries; Aryan Vink; Evelyn Velema; Jan-Albert Vos; Dominique de Kleijn; Frans L Moll; Gerard Pasterkamp |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2010-06-08 |
Journal Detail:
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Title: Journal of vascular surgery Volume: 52 ISSN: 1097-6809 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-27 Revised Date: 2012-10-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 592-9 Citation Subset: IM |
Affiliation:
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Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Occlusive Diseases / pathology, surgery*, ultrasonography Chi-Square Distribution Constriction, Pathologic Endarterectomy* / adverse effects Female Femoral Artery / pathology, surgery*, ultrasonography Humans Logistic Models Male Middle Aged Netherlands Odds Ratio Recurrence Risk Assessment Risk Factors Severity of Illness Index Time Factors Treatment Outcome Ultrasonography, Doppler, Duplex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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