Document Detail

"Histologic Chorioamnionitis as a Consideration in the Management of Newborns of Febrile Mothers"
MedLine Citation:
PMID:  23211126     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Chorioamnionitis (CA) presents a risk for neonatal sepsis, but its diagnosis remains a challenge. Maternal fever is often used as a clinical predictor of infection, but may be affected by other factors. There is no consensus among neonatologists regarding the length of treatment of babies born to febrile mothers with negative blood culture, but whose placentas are positive for presence of histologic CA (HCA). OBJECTIVES: A prospective observational cohort study was conducted on term infants to determine the association of HCA with C-reactive protein (CRP) and elevated Immature/Total neutrophil (I/T) ratio and other perinatal factors. METHODS: I/T ratio, CRP, blood culture, and placental pathology were performed on 100 infants born to mothers with temperature >/= 100.4(o)F. Placental pathology performed on 100 control infants born to afebrile mothers. RESULTS: There was a significant association between HCA and MF. The presence of elevated CRP was associated with HCA. There was no significant association between HCA and anesthesia, mode of delivery, nor elevated I/T ratio. CONCLUSIONS: Maternal fever is associated with HCA. HCA in conjunction with an elevated CRP can guide the duration of antimicrobial therapy in infants born to febrile mothers.
Danthanh Hoang; Pradeepkumar Charlagorla; Carolyn Salafia; Samantha Vanhorn; Beata Dygulska; Pramod Narula; Ashraf Gad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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