Document Detail

Histogenetic aspects of deer antler development .
MedLine Citation:
PMID:  23277003     Owner:  NLM     Status:  In-Data-Review    
Deer antlers are the only mammalian organs that, once lost, can fully grow back; therefore, they offer a unique opportunity for investigating the mechanism underlying mammalian organ regeneration. This review summarizes the current knowledge of antler histogenesis. The axis of a pedicle (antecedent of antler) and a first antler consists of an internal component and an external component. Formation of the internal component commences from the proliferation of antlerogenic periosteal cells and undergoes 4 ossification stages: Formation of the external component goes through 3 distinguishable stages. Antler velvet transformation is mainly associated with alteration in the skin appendages. Subsequent antler regeneration is divided into 5 stages. The present account, together with the companion paper on antler morphogenesis in this special issue (E4, 1836-1842), provides a foundation for further mechanistic study of this fascinating model for mammalian organ regeneration.
Chunyi Li
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-89     Citation Subset:  IM    
AgResearch Invermay Agricultural Centre, Mosgiel, New Zealand.
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