Document Detail


Histogenesis of diffuse small cleaved cell lymphoma. An immunohistochemical and molecular genetic (bcl-2 gene) study with comparison to follicular small cleaved cell lymphoma and mantle zone lymphoma.
MedLine Citation:
PMID:  1643614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunohistochemical and molecular genetic (bcl-2 gene) studies were performed on specimens from 24 patients with follicular small cleaved cell lymphoma (FSCCL), 24 patients with diffuse small cleaved cell lymphoma (DSCCL) and 4 patients with mantle zone lymphoma (MZL) to determine the cellular origin of the disease and whether or not DSCCL represents the diffuse counterpart of FSCCL. Two patients with FSCCL, 22 patients with DSCCL, and all of the patients with MZL had a phenotype of mantle zone (MZ) B-lymphocytes (SIgD+, Leu-1+, Leu-8+, positive alkaline phosphatase [ALPase+], and negative common acute lymphoblastic leukemia antigen [CALLA-]), and all the tested patients (2 patients with FSCCL, 13 patients with DSCCL, and 4 patients with MZL) had germlines of bcl-2 gene. Fourteen patients with FSCCL and 1 patient with DSCCL had a phenotype of follicular center cells (FCC) (CALLA+, SIgD-, Leu-1-, Leu-8- and negative ALPase), and 11 patients with FSCCL had bcl-2 gene rearrangements. These results indicate that FSCCL are almost always derived from FCC, whereas some FSCCL, most DSCCL, and all MZL are derived from MZ B-lymphocytes, and these lymphomas should be included in the same category as MZ B-lymphocyte-derived lymphomas. Histologically diagnosed DSCCL often may represent a diffuse counterpart of MZ B-lymphocyte-derived lymphoma. MZ B-lymphocyte-derived lymphomas histologically show a follicular (nodular), a follicular MZ, or a diffuse growth pattern and clinically show a high incidence of peripheral blood (PB) involvement or bone marrow (BM) involvement.
Authors:
M Abe; N Ono; K Tominaga; H Hojo; M Seto; S Fukuhara; H Wakasa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  70     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-08     Completed Date:  1992-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  821-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Fukushima Medical College, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Blotting, Southern
DNA, Neoplasm / analysis,  genetics
Female
Humans
Immunohistochemistry
Lymphoid Tissue / cytology,  physiology
Lymphoma, Follicular / etiology*,  genetics,  pathology
Lymphoma, Non-Hodgkin / etiology*,  genetics,  pathology
Male
Middle Aged
Molecular Biology
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-cbl
Ubiquitin-Protein Ligases*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Proto-Oncogene Proteins; EC 6.3.2.-/CBL protein, human; EC 6.3.2.-/Proto-Oncogene Proteins c-cbl; EC 6.3.2.19/Ubiquitin-Protein Ligases

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