Document Detail


Histocompatibility antigens in small cell carcinoma of the lung.
MedLine Citation:
PMID:  6093986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty white patients with small cell carcinoma of the lung (SCCL) were typed for histocompatibility antigens (HLA) to assist in providing platelet support for intensive induction therapy. An analysis of the HLA types in this population was undertaken to determine if there was an influence of HLA type on this disease. Patients with the HLA-Bw44 (HLA-B12) allele were found to be significantly over-represented in our patient population compared to a control population (52% versus 26%, P less than 0.001). In addition, patients possessing the HLA-A1 phenotype were found to have a significantly poorer 1-year survival rate (15%) than individuals who did not possess this allele (60% 1-year survival rate) (P less than 0.025). These findings will need to be confirmed by other groups working with large numbers of patients with SCCL.
Authors:
M Markman; H G Braine; M D Abeloff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  54     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-24     Completed Date:  1985-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2943-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Small Cell / genetics,  immunology*
HLA Antigens / analysis*
Humans
Lung Neoplasms / genetics,  immunology*
Phenotype
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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