Document Detail

Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies.
MedLine Citation:
PMID:  2128808     Owner:  NLM     Status:  MEDLINE    
A number of studies suggest that there is a genetic basis for the formation by some haemophilia A patients of antibodies that inactivate factor VIII. In our study, human leucocyte antigen (HLA)-A, B, C, DR and DQ typing was carried out for 44 haemophilia A patients, including 16 who had developed an antibody to factor VIII. In contrast to previous reports, we found no association between HLA-DR antigens and haemophilia A per se or the formation of a factor VIII inhibitor. However, there was an absence of HLA-Cw5 in the 16 haemophilic patients who had formed an antibody to factor VIII. This finding, consistent with a previous report, identified a statistically significant difference in HLA-Cw5 frequency when the inhibitor patient group was compared to multi-transfused haemophilic patients who had no inhibitor (11/28).
A M Aly; L M Aledort; T D Lee; L W Hoyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  76     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-07-02     Completed Date:  1991-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  238-41     Citation Subset:  IM    
Holland Laboratory, American Red Cross Blood Services, Rockville, MD 20855.
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MeSH Terms
Autoantibodies / analysis*
Child, Preschool
Factor VIII / immunology*
HLA Antigens / analysis*
HLA-A Antigens / analysis
HLA-B Antigens / analysis
HLA-C Antigens / analysis
Hemophilia A / immunology*
Middle Aged
Reference Values
Reg. No./Substance:
0/Autoantibodies; 0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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