Document Detail

Histochemical study on neurodegeneration in the olfactory bulb after transient forebrain ischaemia in the Mongolian gerbil.
MedLine Citation:
PMID:  15239811     Owner:  NLM     Status:  MEDLINE    
In the present study, we investigated the ischaemia-related neurodegeneration in the main and accessory olfactory bulb (AOB) after 5 min transient forebrain ischaemia in the Mongolian gerbil using the acid fuchsin staining method. Between 5 and 15 days after ischaemia, acid fuchsin positive cells markedly increased in the external plexiform layer (EPL), mitral cell layer (ML) and glomerular layer (GL) of the main olfactory bulb (MOB), and in the mixed cell layer (MCL) and GL of the AOB. By 30 days after ischaemia reperfusion, acid fuchsin positive neurons were shrunken and showed low acidophilia in somata. Many necrotic vacuoles were found in the EPL and GL of the MOB 30 days after ischaemia. At this time, necrotic vacuoles were very few in the AOB. Therefore, our results suggest that the GL and EPL of the MOB are vulnerable to ischaemic damage at a later time after ischaemic insult, and that the AOB is more resistant to ischaemic damage as compared with the MOB.
U S Koh; I K Hwang; J C Lee; H Y Lee; N S Seong; H G Chung; J H Kim; H J Lee; G P Choi; T-C Kang; M H Won
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomia, histologia, embryologia     Volume:  33     ISSN:  0340-2096     ISO Abbreviation:  Anat Histol Embryol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704218     Medline TA:  Anat Histol Embryol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  IM    
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
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MeSH Terms
Immunohistochemistry / veterinary
Ischemic Attack, Transient / complications,  pathology,  veterinary*
Neurodegenerative Diseases / etiology,  pathology,  veterinary*
Olfactory Bulb / anatomy & histology,  pathology*
Prosencephalon / blood supply,  pathology
Rodent Diseases / pathology*

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