| Histochemical study of lectin binding in the human fetal minor salivary glands. | |
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MedLine Citation:
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PMID: 7776265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The emerging synthesis of glycoconjugates containing specific oligosaccharides in developing human fetal labial and lingual salivary glands has been investigated by lectin histochemistry. An avidin-biotin technique was used to study the binding of lectins from Ulex europeus I (UEA-I), Dolichos biflorus (DBA), Glycine maximus (SBA), Helix pomatia (HPA), Arachis hypogaea (PNA) and Triticum vulgare (WGA) to specific sugars on sections of tissue from labial glands, glands of Blandin and Nuhn, glands of von Ebner and the dorsoposterior lingual salivary glands. Incipient synthesis of glycoconjugates in early glands and their presence in the cells and ducts of the later glands was shown. The study also showed a time-related increase in both staining intensity and binding sites of serous acinar cells from all glands and for all lectins used. For mucous cells, peak intensity of staining was reached by the middle phase of development. During later gland development this intensity was maintained in dorsoposterior lingual glands but tended to decline in labial glands. The various lectins showed different degrees of binding but UEA-I lectin generally bound the L-fucose sugar group in all salivary glands at all gestational ages. The results showed that lectins appear to bind to the oligosaccharides on epithelial cell surfaces of fetal salivary glands at all stages of development. The degree of change depends upon the stage of differentiation and maturation of the glands. |
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Authors:
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M M Adi; D M Chisholm; J P Waterhouse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 24 ISSN: 0904-2512 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-07-07 Completed Date: 1995-07-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: DENMARK |
Other Details:
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Languages: eng Pagination: 130-5 Citation Subset: D; IM |
Affiliation:
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Department of Dental Surgery and Periodontology, University of Dundee, Scotland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylgalactosamine
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metabolism Acetylglucosamine / metabolism Epithelium / embryology, metabolism Fetus Fucose / metabolism Galactose / metabolism Gestational Age Histocytochemistry Humans Lectins / metabolism* Lip / embryology*, metabolism* Mucous Membrane / embryology, metabolism Protein Binding Salivary Glands, Minor / embryology*, metabolism* Serous Membrane / embryology, metabolism Sialic Acids / metabolism Tongue / embryology*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 0/Sialic Acids; 26566-61-0/Galactose; 31022-50-1/Acetylgalactosamine; 3713-31-3/Fucose; 7512-17-6/Acetylglucosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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