Document Detail

Histochemical studies on the distribution of certain dehydrogenases in squamous cell carcinoma of cheek.
MedLine Citation:
PMID:  2777329     Owner:  NLM     Status:  MEDLINE    
Histochemical distribution of lactate, isocitrate and succinate dehydrogenases in normal oral epithelium and in well differentiated squamous cell carcinoma of cheek region was studied. Lactate dehydrogenase, isocitrate dehydrogenase, and succinate dehydrogenase activity was found to be more in the malignant cells. Succinate and lactate dehydrogenase presented a conspicuous pattern in which the cells located at the periphery of the malignant sheets in well differentiated squamous cell carcinoma showed moderate to intense activity as compared to cells in the central portion. The results are discussed and it is suggested that the enhanced glycolysis and subdued function of the tricarboxylic acid cycle is not a universal criterion during malignancy as reported in the previous investigations.
S Banerjee; D K Bhatt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of cancer     Volume:  26     ISSN:  0019-509X     ISO Abbreviation:  Indian J Cancer     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0112040     Medline TA:  Indian J Cancer     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Squamous Cell / enzymology*,  pathology
Middle Aged
Mouth Mucosa
Mouth Neoplasms / enzymology*,  pathology
Oxidoreductases / metabolism*
Reg. No./Substance:
EC 1.-/Oxidoreductases

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