Document Detail

Histochemical, immunohistochemical and ultrastructural investigations of giant cell tumors of bone.
MedLine Citation:
PMID:  2426919     Owner:  NLM     Status:  MEDLINE    
The origin and characteristics of so-called stromal cells (stromal cell) and the osteoclast-like giant cell series of 19 cases of giant cell tumor (G.C.T.) of bone were studied. Immunohistochemically, two interesting cases were found. The stromal cells of one case were alpha-1-antitrypsin positive and those of the other case were alpha-1-antichymotrypsin positive. The histiocytic stromal cells of the latter case seemed to be surely neoplastic since they showed mild to moderate cell atypism. There were foci consisting of fibroblastic cells or osteoid and osteoblasts within the tumor. Those cells in the foci were apparently continuous with the surrounding stromal cells, and they were, therefore, also considered to be neoplastic. These findings strongly indicate that the stromal cells originate from the undifferentiated mesenchymal cells in the bone marrow and may differentiate to osteoblastic, fibroblastic, and histiocytic cells. All cells of these three series were not stained for a high stable form of acid phosphatase (SAPhase). SAPhase activity was demonstrated only in osteoclast-like giant cells and some mononuclear cells, which are recently believed to be non-neoplastic. Therefore, the cell atypia of SAPhase negative stromal cells is considered to have a prognostic value.
I Emura; Y Inoue; Y Ohnishi; T Morita; H Saito; T Tajima
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  36     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  691-702     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase
Bone Neoplasms / analysis*,  ultrastructure
Carcinoma / analysis*,  ultrastructure
Giant Cell Tumors / analysis*,  ultrastructure
Immunoenzyme Techniques
Microscopy, Electron
Staining and Labeling
Reg. No./Substance:
EC Phosphatase

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