Document Detail

Histochemical and immunohistochemical evidence of glandular differentiation in thymic carcinoma.
MedLine Citation:
PMID:  2477989     Owner:  NLM     Status:  MEDLINE    
Eighteen cases of primary thymic carcinoma were reviewed from the viewpoint of glandular differentiation. Squamous differentiation was evident in 14 cases (83%). Immunohistochemical study revealed secretory component (SC)-positive carcinoma cells in 12 cases (67%), most of which were also associated with squamous differentiation. Three of these 12 cases contained areas with a definite glandular or microcystic structure with occasional epithelial mucin, and were diagnosed as adenosquamous carcinoma. Review of patients' medical records revealed that thymic carcinomas with a glandular element were more often resectable at surgery, and had a much better prognosis than those without a glandular element. However, further study on larger number of cases is necessary to confirm this relationship. Because SC-positive epithelial cells do exist in the non-neoplastic thymus, the presence of a glandular component suggests another direction of morphological and/or functional differentiation of thymic carcinoma cells in addition to the well-known squamous differentiation.
Y Matsuno; K Mukai; M Noguchi; Y Sato; Y Shimosato
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  39     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-30     Completed Date:  1989-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  433-8     Citation Subset:  IM    
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan.
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MeSH Terms
Carcinoma / analysis,  pathology*,  surgery
Carcinoma, Squamous Cell / analysis,  pathology
Cell Differentiation
Cell Transformation, Neoplastic / analysis,  pathology
Keratins / analysis
Thymus Gland / analysis,  pathology*
Thymus Neoplasms / analysis,  pathology*,  surgery
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Tumor Markers, Biological; 68238-35-7/Keratins

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