Document Detail

Histochemical demonstration of heavy metals in mouse skin.
MedLine Citation:
PMID:  8607288     Owner:  NLM     Status:  MEDLINE    
The localization of heavy metals in normal mouse skin was investigated light microscopically using the Neo-Timm staining method. Positive staining was found in the horny layer of epidermis, connective tissue of dermis and in hair roots. Chelation of heavy metals by pretreatment with diethyldithiocarbamate prevented this staining. The study demonstrates that heavy metals, mainly zinc, are localized in the mouse skin and that the Neo-Timm staining method is useful for the investigation of the role of zinc in this organ.
L Jin; T H Murakami; N A Janjua; T Itano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  97     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-05-20     Completed Date:  1996-05-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Department of Biology, Kagawa Medical School, Japan.
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MeSH Terms
Chelating Agents / pharmacology
Coloring Agents / chemistry
Connective Tissue / chemistry*,  drug effects
Ditiocarb / pharmacology
Dose-Response Relationship, Drug
Eosine Yellowish-(YS) / chemistry
Epidermis / chemistry*,  drug effects
Hair / chemistry*,  drug effects
Hematoxylin / chemistry
Metals / analysis*,  metabolism
Silver Staining
Skin / chemistry*,  drug effects
Staining and Labeling
Sulfides / chemistry
Zinc / analysis,  metabolism
Reg. No./Substance:
0/Chelating Agents; 0/Coloring Agents; 0/Metals; 0/Sulfides; 147-84-2/Ditiocarb; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin; 7440-66-6/Zinc

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