| Histochemical and chronological analysis of mouse submandibular gland parenchyma subjected to abrupt reperfusion. | |
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MedLine Citation:
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PMID: 12792899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of abrupt reperfusion on the mouse submandibular gland parenchyma and determined the degree of recovery from tissue damage. A main trophic artery supplying the gland was ligated with silk thread, and the ligature was then released after a variable period. The gland was removed at various times after reperfusion and then examined immunohistochemically and ultrastructurally. With reperfusion after 15 or 30 min of ligation, the tissue damage to the glands was slight or inapparent. With reperfusion after 1 or 3 h of ligation, collapse of the acini and the ducts was observed in parts of the lobules, but restoration of the parenchymal structures occurred, with the appearance of PCNA-positive cells, although there were differences in the level of restoration. After 6 h of ligation, most of the normal parenchymal cells had disappeared by the 5th and 7th days after reperfusion, and apoptosis and necrosis were present. These findings suggest that if interruption of the blood supply to the submandibular gland parenchyma is limited to within a few hours, then tissue repair after reperfusion is possible, although this will differ according to the level of damage, because the acini and the ducts reappear, probably with proliferation of parenchymal cells. |
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Authors:
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Y Fujisawa; S Aiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histology and histopathology Volume: 18 ISSN: 0213-3911 ISO Abbreviation: Histol. Histopathol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-06 Completed Date: 2004-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 871-8 Citation Subset: IM |
Affiliation:
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Department of Histology, The Nippon Dental University School of Dentistry at Tokyo, Japan. Yuka.43@b5.mnx.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcian Blue
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pharmacology Animals Apoptosis Cell Division In Situ Nick-End Labeling Male Mice Mice, Inbred ICR Microscopy, Electron Necrosis Proliferating Cell Nuclear Antigen / pharmacology Reperfusion Submandibular Gland / blood supply, pathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Proliferating Cell Nuclear Antigen; 12040-44-7/Alcian Blue |
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