Document Detail

Histochemical and chronological analysis of mouse submandibular gland parenchyma subjected to abrupt reperfusion.
MedLine Citation:
PMID:  12792899     Owner:  NLM     Status:  MEDLINE    
We examined the effects of abrupt reperfusion on the mouse submandibular gland parenchyma and determined the degree of recovery from tissue damage. A main trophic artery supplying the gland was ligated with silk thread, and the ligature was then released after a variable period. The gland was removed at various times after reperfusion and then examined immunohistochemically and ultrastructurally. With reperfusion after 15 or 30 min of ligation, the tissue damage to the glands was slight or inapparent. With reperfusion after 1 or 3 h of ligation, collapse of the acini and the ducts was observed in parts of the lobules, but restoration of the parenchymal structures occurred, with the appearance of PCNA-positive cells, although there were differences in the level of restoration. After 6 h of ligation, most of the normal parenchymal cells had disappeared by the 5th and 7th days after reperfusion, and apoptosis and necrosis were present. These findings suggest that if interruption of the blood supply to the submandibular gland parenchyma is limited to within a few hours, then tissue repair after reperfusion is possible, although this will differ according to the level of damage, because the acini and the ducts reappear, probably with proliferation of parenchymal cells.
Y Fujisawa; S Aiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  18     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-06     Completed Date:  2004-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  871-8     Citation Subset:  IM    
Department of Histology, The Nippon Dental University School of Dentistry at Tokyo, Japan.
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MeSH Terms
Alcian Blue / pharmacology
Cell Division
In Situ Nick-End Labeling
Mice, Inbred ICR
Microscopy, Electron
Proliferating Cell Nuclear Antigen / pharmacology
Submandibular Gland / blood supply,  pathology*
Time Factors
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 12040-44-7/Alcian Blue

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