Document Detail

Histochemical assay of estrogen and progesterone receptors in breast cancer: correlation with biochemical assays and patients' response to endocrine therapies.
MedLine Citation:
PMID:  6256056     Owner:  NLM     Status:  MEDLINE    
Estrogen (ER) and progesterone (PgR) receptors were assayed by histochemistry in primary, recurrent, and metastatic breast cancer. Ligand-conjugates composed of 17 beta-estradiol and 11 alpha-hydroxyprogesterone covalently linked to bovine serum albumin and labelled with fluorescein isothiocyanate were employed. Results were compared with those of conventional biochemical receptor assays and correlated for ER in 92% of 314 tumors and for PgR in 86% of 86 specimens. ER and PgR determinations by both assay systems were correlated with clinical response to various endocrine therapies in 40 women with Stage IV disease. The histochemical assay enabled successful prediction of response in 80% of cases including eight which could not be fully analyzed biochemically.
L P Pertschuk; E H Tobin; E Gaetjens; A C Carter; G A Degenshein; N D Bloom; D J Brigati
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  46     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2896-901     Citation Subset:  AIM; IM    
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MeSH Terms
Binding, Competitive
Breast Neoplasms / analysis*,  therapy
Carcinoma, Intraductal, Noninfiltrating / analysis,  therapy
Centrifugation, Density Gradient
Diethylstilbestrol / therapeutic use
Fluorescent Antibody Technique
Fluoxymesterone / therapeutic use
Neoplasm Metastasis
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Tamoxifen / therapeutic use
Grant Support
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; 10540-29-1/Tamoxifen; 56-53-1/Diethylstilbestrol; 76-43-7/Fluoxymesterone

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