Document Detail

Histiocytosis X of the vulva: a case report and review of the literature.
MedLine Citation:
PMID:  2406669     Owner:  NLM     Status:  MEDLINE    
Histiocytosis X of the female genital tract is unusual. Thirty-two cases have been reported to date in the world literature. An additional case is reported herein, presenting as a vulvar ulcer in a 2.5-year-old child with osteolytic lesions of the skull, splenomegaly, and otitis media. The diagnosis of histiocytosis X may be established by identifying the Langerhans histiocyte, characterized by nuclear grooves, immunoreactivity for S-100 protein, and pentalamellar cytoplasmic structures seen by electron microscopy. Prognosis is difficult to determine with certainty. However, age of less than 2 years at presentation, multi-organ involvement, and/or organ dysfunction appear to be associated with a less favorable prognosis. The patient presented herein is currently receiving vinblastine chemotherapy for recurrence of disease, manifested as an osteolytic lesion in the skull.
C N Otis; R A Fischer; N Johnson; J F Kelleher; J L Powell
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  75     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-03-20     Completed Date:  1990-03-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  555-8     Citation Subset:  AIM; IM    
Department of Pathology, Baystate Medical Center, Springfield, Massachusetts.
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MeSH Terms
Bone Diseases / pathology
Child, Preschool
Histiocytosis, Langerhans-Cell* / diagnosis,  pathology,  therapy
Vulvar Diseases* / diagnosis,  pathology,  therapy

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