Document Detail

Histiocytosis X and pregnancy.
MedLine Citation:
PMID:  7724119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Histiocytosis X, a clinically heterogeneous infiltrating disorder, is rarely associated with pregnancy. Diabetes insipidus is a common manifestation of histiocytosis X. CASE: A 27-year-old pregnant woman was diagnosed with histiocytosis X by biopsy. At 31 weeks' gestation, she developed diabetes insipidus and required treatment with intranasal 8-D-arginine vasopressin. A hypothalamic mass was noted on magnetic resonance imaging. She delivered a 363-g male at term by cesarean. Two months postpartum, after a motor vehicle accident, she developed a T6 sensory and motor deficit. An intramedullary spinal cord mass was diagnosed and surgically removed. She was treated postoperatively with radiation therapy to the spine and hypothalamus. Despite systemic chemotherapy, the disease progressed, and the patient died 18 months after delivery. CONCLUSION: Pregnancy in patients suffering from histiocytosis X is rare. When pregnancy and histiocytosis X do coincide, diabetes insipidus may appear or worsen. Treatment with intranasal 8-D-arginine vasopressin does not pose risks for the fetus or for premature labor.
L A DiMaggio; H A Lippes; R V Lee
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  85     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-05-22     Completed Date:  1995-05-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  806-9     Citation Subset:  AIM; IM    
Department of Medicine, State University of New York at Buffalo, USA.
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MeSH Terms
Accidents, Traffic
Arginine Vasopressin / therapeutic use
Cesarean Section
Diabetes Insipidus / complications,  drug therapy,  etiology
Fatal Outcome
Histiocytosis, Langerhans-Cell / complications,  diagnosis*,  etiology,  radiotherapy
Hypothalamus / radiation effects
Infant, Newborn
Magnetic Resonance Imaging*
Pregnancy Complications* / diagnosis,  therapy
Spinal Cord / radiation effects
Spinal Cord Diseases / diagnosis*,  etiology,  radiotherapy
Reg. No./Substance:
113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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