Document Detail

Histiocytoid cardiomyopathy: case report and literature review.
MedLine Citation:
PMID:  8263485     Owner:  NLM     Status:  MEDLINE    
The sudden death of an infant may be due to a variety of causes. In such cases, complete autopsy with radiologic, gross, microscopic, and toxicologic examination is warranted. We present a case of a previously healthy 15-month-old girl with no known disease, who experienced witnessed cardiac arrest, ventricular fibrillation, and death. Complete postmortem examination revealed histiocytoid cardiomyopathy as the cause of death. Histiocytoid cardiomyopathy is a rare infantile cardiac-muscle disorder characterized by the presence of enlarged, polygonal subendocardial myocytes which, by light microscopy, lack normal striations, and instead have granular, faintly eosinophilic cytoplasm. Ultrastructurally, the myocytes contain numerous mitochondria and markedly reduced numbers of myofibrils. Clinically, the disorder is characterized by cardiac arrhythmias and/or sudden death occurring in children under the age of two years. We discuss the differential diagnosis, proposed theories of etiology, and the pathology of this rare entity.
J A Prahlow; L A Teot
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  38     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-01-25     Completed Date:  1994-01-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1427-35     Citation Subset:  IM    
Department of Pathology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.
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MeSH Terms
Cardiomyopathies / complications,  pathology*
Fatal Outcome
Heart Arrest / etiology*
Microscopy, Electron

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