Document Detail

Histidine--rich glycoprotein in the blood of the bivalve Mytilus edulis: role in cadmium speciation and cadmium transfer to the kidney.
MedLine Citation:
PMID:  11164535     Owner:  NLM     Status:  MEDLINE    
Cadmium transfer from M. edulis L. blood plasma to tissues was investigated in relation to its chemical speciation in the blood. 109Cd was injected into the posterior adductor muscle along with synthetic chelators oxine, ethylenediaminetetraacetic acid (EDTA) or cyclohexanediaminetetraacetic acid (CDTA). Chelator concentrations were chosen to bind up from 0 to 98.7% of the total blood Cd, based on speciation calculations using the geochemical speciation model MINTEQA2. Increases in synthetically chelated Cd were accompanied by linear decreases in the calculated percentages of Histidine-rich Glycoprotein (HRG)-bound Cd, and nonlinear decreases in Cd(2+) and Cd chloro-complexes. Cadmium uptake by the kidneys decreased with increasing percentage synthetic chelation, while uptake by other tissues was not affected by chelation. Results indicate that there is at least one mechanism of Cd uptake common to all M. edulis tissues, and an additional, more rapid uptake mechanism in the kidneys that is mediated by CdHRG.
P Satish Nair; W E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Aquatic toxicology (Amsterdam, Netherlands)     Volume:  52     ISSN:  0166-445X     ISO Abbreviation:  Aquat. Toxicol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500246     Medline TA:  Aquat Toxicol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
Environmental, Coastal and Ocean Sciences Department, University of Massachusetts Boston, Harbor Campus, MA, Boston 02125-3393, USA.
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MeSH Terms
Biological Transport, Active
Bivalvia / metabolism*
Cadmium / pharmacokinetics*
Kidney / metabolism*
Proteins / metabolism*
Reg. No./Substance:
0/Proteins; 0/histidine-rich proteins; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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