Document Detail

Histidine kinases play important roles in the perception and signal transduction of hydrogen peroxide in the cyanobacterium, Synechocystis sp. PCC 6803.
MedLine Citation:
PMID:  17181779     Owner:  NLM     Status:  MEDLINE    
Oxidative stress caused by reactive oxygen species and, in particular, to hydrogen peroxide (H(2)O(2)) has a major impact on all biological systems, including plants and microorganisms. We investigated the H(2)O(2)-inducible expression of genes in the cyanobacterium Synechocystis sp. PCC 6803 using genome-wide DNA microarrays. Our systematic screening of a library of mutant lines with defects in histidine kinases (Hiks) by RNA slot-blot hybridization and DNA-microarray analysis suggested that four Hiks, namely, Hik33, Hik34, Hik16 and Hik41, are involved in the perception and transduction of H(2)O(2) signals that regulate the gene expression of 26 of the 77 H(2)O(2)-inducible genes with induction factors higher than 4.0. Among the four Hiks, Hik33 was the main contributor and was responsible for 22 of the 26 H(2)O(2)-inducible genes under the control of the Hiks. By contrast to Hik33, PerR encoding putative peroxide-sensing protein is involved in the regulation of only nine H(2)O(2)-inducible genes.
Yu Kanesaki; Hiroshi Yamamoto; Kalyanee Paithoonrangsarid; Maria Shoumskaya; Iwane Suzuki; Hidenori Hayashi; Norio Murata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-20
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  49     ISSN:  0960-7412     ISO Abbreviation:  Plant J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-07-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-24     Citation Subset:  IM    
National Institute for Basic Biology, Okazaki 444-8585, Japan.
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MeSH Terms
Bacterial Proteins / genetics*,  metabolism
Blotting, Northern
Cyanobacteria / drug effects,  enzymology,  genetics*
Gene Expression Regulation, Bacterial / drug effects
Hydrogen Peroxide / pharmacology*
Isoenzymes / genetics,  metabolism
Models, Genetic
Oligonucleotide Array Sequence Analysis
Protein Kinases / genetics*,  metabolism
Signal Transduction / genetics
Reg. No./Substance:
0/Bacterial Proteins; 0/Isoenzymes; 7722-84-1/Hydrogen Peroxide; EC 2.7.-/Protein Kinases; EC 2.7.3.-/protein-histidine kinase

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