| Histidine kinases play important roles in the perception and signal transduction of hydrogen peroxide in the cyanobacterium, Synechocystis sp. PCC 6803. | |
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MedLine Citation:
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PMID: 17181779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress caused by reactive oxygen species and, in particular, to hydrogen peroxide (H(2)O(2)) has a major impact on all biological systems, including plants and microorganisms. We investigated the H(2)O(2)-inducible expression of genes in the cyanobacterium Synechocystis sp. PCC 6803 using genome-wide DNA microarrays. Our systematic screening of a library of mutant lines with defects in histidine kinases (Hiks) by RNA slot-blot hybridization and DNA-microarray analysis suggested that four Hiks, namely, Hik33, Hik34, Hik16 and Hik41, are involved in the perception and transduction of H(2)O(2) signals that regulate the gene expression of 26 of the 77 H(2)O(2)-inducible genes with induction factors higher than 4.0. Among the four Hiks, Hik33 was the main contributor and was responsible for 22 of the 26 H(2)O(2)-inducible genes under the control of the Hiks. By contrast to Hik33, PerR encoding putative peroxide-sensing protein is involved in the regulation of only nine H(2)O(2)-inducible genes. |
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Authors:
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Yu Kanesaki; Hiroshi Yamamoto; Kalyanee Paithoonrangsarid; Maria Shoumskaya; Iwane Suzuki; Hidenori Hayashi; Norio Murata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-20 |
Journal Detail:
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Title: The Plant journal : for cell and molecular biology Volume: 49 ISSN: 0960-7412 ISO Abbreviation: Plant J. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-23 Completed Date: 2007-07-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9207397 Medline TA: Plant J Country: England |
Other Details:
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Languages: eng Pagination: 313-24 Citation Subset: IM |
Affiliation:
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National Institute for Basic Biology, Okazaki 444-8585, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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genetics*,
metabolism Blotting, Northern Cyanobacteria / drug effects, enzymology, genetics* Gene Expression Regulation, Bacterial / drug effects Hydrogen Peroxide / pharmacology* Isoenzymes / genetics, metabolism Models, Genetic Oligonucleotide Array Sequence Analysis Protein Kinases / genetics*, metabolism Signal Transduction / genetics |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Isoenzymes; 7722-84-1/Hydrogen Peroxide; EC 2.7.-/Protein Kinases; EC 2.7.3.-/protein-histidine kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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