Document Detail

Histatins enhance wound closure with oral and non-oral cells.
MedLine Citation:
PMID:  19767583     Owner:  NLM     Status:  MEDLINE    
The role of human saliva in oral wound-healing has never been fully elucidated. We previously demonstrated that parotid-salivary histatins enhance in vitro wound closure. The question remains whether other salivary-gland secretions enhance wound closure, and also the effects of histatins on primary and non-oral cells. Since the presence of histatins is not limited to parotid saliva, we expected to observe wound-closure activity of other salivary-gland secretions. However, here we show that non-parotid saliva does not stimulate wound closure, most probably due to the presence of mucins, since the addition of MUC5B to parotid saliva abolished its effect. Furthermore, we found that histatins stimulated wound closure of (primary) cells of both oral and non-oral origin. This suggests that the cellular receptor of histatins is widely expressed and not confined to cells derived from the oral cavity. These findings encourage the future therapeutic application of histatins in the treatment of all kinds of wounds.
M J Oudhoff; P A M van den Keijbus; K L Kroeze; K Nazmi; S Gibbs; J G M Bolscher; E C I Veerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dental research     Volume:  88     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  846-50     Citation Subset:  D; IM    
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Cell Line
Cell Line, Tumor
Cells, Cultured
Dermis / cytology,  drug effects
Epidermal Growth Factor / pharmacology
Epithelial Cells / drug effects
Fibroblast Growth Factor 6 / pharmacology
Fibroblasts / drug effects
Gingiva / cytology,  drug effects
Histatins / pharmacology*
Infant, Newborn
Mouth Mucosa / cytology*,  drug effects
Mucin-5B / pharmacology
Mucins / pharmacology
Parotid Gland / secretion
Recombinant Proteins
Saliva / chemistry
Salivary Proteins and Peptides / pharmacology*
Submandibular Gland / secretion
Wound Healing / drug effects*
Young Adult
Reg. No./Substance:
0/FGF6 protein, human; 0/Fibroblast Growth Factor 6; 0/Histatins; 0/MUC5B protein, human; 0/Mucin-5B; 0/Mucins; 0/Recombinant Proteins; 0/Salivary Proteins and Peptides; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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