| Histaminergic drugs in the rat caudate nucleus: effects on learned helplessness. | |
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MedLine Citation:
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PMID: 8327534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of pharmacological manipulation of histaminergic receptors in the caudate nucleus (CN) has been examined in rats previously submitted to inescapable electric shock to produce learned helplessness (LH). Histamine H1 agonist 2-tiazolylethyl amine (TEA) microinjection produced protective effects, preventing the activity and cognitive loss typical in LH. Injection of the H1 antagonist astemizole (AZ) produced effects symmetrical to those produced by TEA, further reducing activity and impairing cognitive functions. The histamine H2 agonist 4-methyl-histamine (4MH) produced a shift on the side preference for rotation that interfered in the learning tests and obscured the effects of this drug on LH. Injection of the H2 antagonist cymetidine (CYM) caused LH-like effects in control animals. Thus, brain histamine seems to play a relevant role in the control of motor and cognitive functions of the CN. |
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Authors:
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J A López-García; C Ramis; M C Nicolau; G Alemany; B Planas; R Rial |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 45 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-08-11 Completed Date: 1993-08-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 275-82 Citation Subset: IM |
Affiliation:
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Department of Biology and H.S., University of the Balearic Islands, Palma de Mallorca, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astemizole / pharmacology Caudate Nucleus / drug effects*, physiology Cimetidine / pharmacology Helplessness, Learned* Histamine Agonists / pharmacology* Histamine Antagonists / pharmacology Male Methylhistamines / pharmacology Rats Rats, Wistar Receptors, Histamine / drug effects, physiology Receptors, Histamine H1 / drug effects, physiology Receptors, Histamine H2 / drug effects, physiology Thiazoles / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Histamine Agonists; 0/Histamine Antagonists; 0/Methylhistamines; 0/Receptors, Histamine; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 0/Thiazoles; 18453-07-1/2-(2-aminoethyl)thiazole; 36507-31-0/4-methylhistamine; 51481-61-9/Cimetidine; 68844-77-9/Astemizole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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