Document Detail


Histamine-releasing properties of T-3762, a novel fluoroquinolone antimicrobial agent in intravenous use. II. Dermovascular permeability-increasing effect and action on peritoneal mast cells.
MedLine Citation:
PMID:  9635500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To predict the actions of T-3762, a newly developed fluoroquinolone antimicrobial agent, as well as ciprofloxacin (CPFX) and ofloxacin (OFLX), on injection sites when dosed parenterally, their ability to increase cutaneous vascular permeability in dogs and to release histamine from rat peritoneal mast cells was examined. CPFX and OFLX increased cutaneous vascular permeability in concentrations ranging from 16 to 32 microg/ml, while T-3762 was inactive at 2000 microg/ml. The vascular permeability-increasing activities of these drugs were inhibited efficiently by pretreatment with a combined dose of diphenhydramine and cimetidine. CPFX induced histamine release from rat mast cells in a dose-dependent manner, whereas T-3762 was ineffective. Therefore, it is concluded that fluoroquinolone antimicrobial agents may have the ability to cause an increase in cutaneous vascular permeability by releasing histamine from mast cells at the injection site when administered parenterally, and that T-3762 has minimum activity among the agents tested in this study.
Authors:
K Furuhata; Y Fukuda; K Soumi; H Arai; Y Watanabe; H Narita
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  21     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  461-4     Citation Subset:  IM    
Affiliation:
Research Laboratories, Toyama Chemical Co., Ltd., Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / administration & dosage,  pharmacology*
Capillary Permeability / drug effects*
Dogs
Female
Fluoroquinolones*
Histamine Release / drug effects*
Male
Mast Cells / drug effects,  metabolism
Peritoneal Cavity / cytology
Rats
Rats, Wistar
Regional Blood Flow / drug effects
Skin / blood supply*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Fluoroquinolones; 0/T 3762

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