Document Detail


Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin.
MedLine Citation:
PMID:  6184258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously reported that flushing associated with a gastric carcinoid tumor can be provoked by pentagastrin and inhibited by either somatostatin or combined histamine H1- and H2-receptor blockade. In this report, the effects of pentagastrin and somatostatin on histamine release in a patient with a metastatic gastric carcinoid tumor were examined. Small doses of intravenous pentagastrin (0.1-0.4 micrograms) produced a dose-dependent increase in the level of circulating plasma histamine. Graded infusions of somatostatin suppressed both basal and pentagastrin-stimulated plasma histamine levels in a dose-dependent fashion. A close correlation was found between circulating plasma histamine levels and attendant changes in blood pressure and pulse rate. This study documents that pentagastrin directly evokes the release of histamine from this patient's gastric carcinoid tumor and that the release of histamine is inhibited by somatostatin. In addition, this study provides additional evidence that the primary mediator of the flushing in this patient with foregut carcinoid syndrome is histamine.
Authors:
L J Roberts; Z T Bloomgarden; S R Marney; D Rabin; J A Oates
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  84     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  272-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Carcinoid Tumor / secretion*
Depression, Chemical
Dose-Response Relationship, Drug
Female
Histamine / blood
Histamine Release / drug effects*
Humans
Middle Aged
Pentagastrin / pharmacology*
Pulse / drug effects
Somatostatin / pharmacology*
Stimulation, Chemical
Stomach Neoplasms / secretion*
Grant Support
ID/Acronym/Agency:
AM022195/AM/NIADDK NIH HHS; GM15431/GM/NIGMS NIH HHS; MO1-RR-0095/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
51-45-6/Histamine; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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