| Histamine release from a gastric carcinoid: provocation by pentagastrin and inhibition by somatostatin. | |
| | |
MedLine Citation:
|
PMID: 6184258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have previously reported that flushing associated with a gastric carcinoid tumor can be provoked by pentagastrin and inhibited by either somatostatin or combined histamine H1- and H2-receptor blockade. In this report, the effects of pentagastrin and somatostatin on histamine release in a patient with a metastatic gastric carcinoid tumor were examined. Small doses of intravenous pentagastrin (0.1-0.4 micrograms) produced a dose-dependent increase in the level of circulating plasma histamine. Graded infusions of somatostatin suppressed both basal and pentagastrin-stimulated plasma histamine levels in a dose-dependent fashion. A close correlation was found between circulating plasma histamine levels and attendant changes in blood pressure and pulse rate. This study documents that pentagastrin directly evokes the release of histamine from this patient's gastric carcinoid tumor and that the release of histamine is inhibited by somatostatin. In addition, this study provides additional evidence that the primary mediator of the flushing in this patient with foregut carcinoid syndrome is histamine. |
| | |
Authors:
|
L J Roberts; Z T Bloomgarden; S R Marney; D Rabin; J A Oates |
Related Documents
:
|
16724698 - Multiple effects of somatostatin analogs verified in three cases of metastasized neuroe... 7630288 - Neuroendocrine neoplasms of the larynx. 10977808 - Membranous nephropathy resolving with treatment of bronchial carcinoid tumor. 1234088 - A huge villous tumor of rectum: a case report. 23026928 - Objective quantification of the ki67 proliferative index in neuroendocrine tumors of th... 22055398 - Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases. |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 84 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1983 Feb |
Date Detail:
|
Created Date: 1983-02-25 Completed Date: 1983-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 272-5 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure
/
drug effects Carcinoid Tumor / secretion* Depression, Chemical Dose-Response Relationship, Drug Female Histamine / blood Histamine Release / drug effects* Humans Middle Aged Pentagastrin / pharmacology* Pulse / drug effects Somatostatin / pharmacology* Stimulation, Chemical Stomach Neoplasms / secretion* |
| Grant Support | |
ID/Acronym/Agency:
|
AM022195/AM/NIADDK NIH HHS; GM15431/GM/NIGMS NIH HHS; MO1-RR-0095/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
51-45-6/Histamine; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Divergence of the two albumins of X. laevis. Evidence for the glycosylation of the major 74K albumin...
Next Document: Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release.