Document Detail


Histamine release and contrast media-induced renal vasoconstriction.
MedLine Citation:
PMID:  9809077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: The authors' purpose was to investigate the role of histamine release causing renal vasoconstriction induced by application of contrast media, an important element in contrast medium-induced nephrotoxicity. MATERIALS AND METHODS: Isometric contractions in rabbit segmental renal arteries stimulated with KCl and increasing concentrations of the ionic contrast medium diatrizoate and the nonionic agents iomeprol and iodixanol were studied both with and without increasing concentrations of the histamine H1 and H2 blockers diphenhydramine and cimetidine. Histamine concentrations after contrast medium application were determined. RESULTS: Contrast-induced, dose-dependent, reversible renal artery contractions of 27%, 4.5%, and 5% of the control KCl contraction were found for diatrizoate, iodixanol, and iomeprol respectively. Those induced by the ionic contrast medium were statistically significantly higher (P < .01). Contractions were partially inhibited by diphenhydramine (49%) but not by cimetidine. Significant elevation of histamine concentrations (P < .05) was detected only after stimulation with diatrizoate but not with nonionic agents. CONCLUSION: Ionic contrast medium induces histamine release leading to renal vasoconstriction, which can be partly blocked by H1 blockers. Histamine has no effect on renal vasospasm induced by nonionic contrast media.
Authors:
P Drescher; J M Knes; P O Madsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  5     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-22     Completed Date:  1999-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  785-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, Medical College of Wisconsin, Milwaukee 53226, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cimetidine / pharmacology
Contrast Media / toxicity*
Culture Techniques
Diatrizoate / toxicity
Diphenhydramine / pharmacology
Dose-Response Relationship, Drug
Histamine H1 Antagonists / pharmacology
Histamine H2 Antagonists / pharmacology
Histamine Release / drug effects*
Iopamidol / analogs & derivatives,  toxicity
Rabbits
Renal Artery / drug effects*
Triiodobenzoic Acids / toxicity
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Triiodobenzoic Acids; 117-96-4/Diatrizoate; 51481-61-9/Cimetidine; 58-73-1/Diphenhydramine; 62883-00-5/Iopamidol; 78649-41-9/iomeprol; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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