Document Detail


Histamine release by pharmacological agents in the absence of external free Ca2+.
MedLine Citation:
PMID:  6207047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The involvement of extracellular free Ca2+ in histamine release was investigated in rat peritoneal mast cells. Incubation of non-antigenized cells in a media with high extracellular potassium did not increase histamine release. Secretion induced by A23187 and compound 48/80 in the presence of Ca2+ requires metabolic energy. In the absence of external free Ca2+ (2.5 microM) histamine release induced by A23187 is reduced but not abolished. Secretion induced by compound 48/80 is independent of extracellular Ca2+. These results lead us to suggest that mast cell plasma membranes probably lack voltage-gated Ca2+ channels and that external Ca2+ may not be an absolute requisite for histamine secretion.
Authors:
E Pintado; M Carrasco; R Goberna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  175     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-13     Completed Date:  1984-11-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcimycin / pharmacology
Calcium / pharmacology*
Female
Glucose / pharmacology
Histamine Release / drug effects*
Kinetics
Male
Mast Cells / immunology*
Potassium / pharmacology
Potassium Cyanide / pharmacology
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
151-50-8/Potassium Cyanide; 50-99-7/Glucose; 52665-69-7/Calcimycin; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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