Document Detail


Histamine-receptor blockade reduces blood flow but not muscle glucose uptake during postexercise recovery in humans.
MedLine Citation:
PMID:  21478258     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Skeletal muscle vasodilation persists following a single bout of exercise and can potentially influence glucose uptake by recovering muscle. To investigate whether blood flow is a rate-limiting component in postexercise muscle glucose uptake, we tested the hypothesis that oral ingestion of H1- and H2-receptor antagonists, known to attenuate the sustained postexercise vasodilation, would reduce leg glucose uptake after a bout of cycling. Healthy, recreationally active subjects (n = 8) exercised for 1-hour at 60% of peak oxygen consumption (VO2peak) on each of two days, with (blockade) and without (control) histamine-receptor antagonism. For 2-h of recovery following exercise, arteriovenous glucose differences were assessed from the radial artery and femoral vein, and leg blood flow was measured using Doppler ultrasonography on the common femoral artery. Femoral blood flow following exercise was 65.4 ± 16.4 ml min-1 lower on the blockade day compared to the control day (P < 0.05). Likewise, glucose delivery was 0.177 ± 0.045 mmol min-1 lower with blockade (P < 0.05). However, histamine-receptor antagonism produced no consistent effect on leg glucose uptake following exercise, due to high interindividual variability. In conclusion, while oral ingestion of H1- and H2-receptor antagonists alters postexercise recovery by attenuating vasodilation, leg glucose uptake is not universally affected in recreationally active individuals.
Authors:
Chi-An W Emhoff; Zachary Barrett-O'Keefe; Richard C Padgett; Jerold A Hawn; John R Halliwill
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 University of Oregon;
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