Document Detail

Histamine and leukotrienes release in bronchoalveolar fluid during plicatic acid-induced bronchoconstriction.
MedLine Citation:
PMID:  2478608     Owner:  NLM     Status:  MEDLINE    
Bronchoalveolar lavage (BAL) was performed before and 10 minutes after inhalation challenge with plicatic acid in five patients with red cedar asthma. There was a significant release of histamine and leukotriene E4 into the BAL fluid in all the patients after challenge. Inhalation challenge with methacholine in six patients with nonoccupational asthma and inhalation challenge with plicatic acid in two subjects without asthma did not result in the release of mediators in the BAL fluid. These studies provide direct evidence that plicatic acid-induced bronchoconstriction was accompanied by increased levels of histamine and leukotriene E4 release, whereas a nonimmunologic induction of bronchoconstriction did not induce such local mediator release. BAL may provide a useful means of studying the pathogenesis of occupational asthma caused by exposure to low-molecular-weight compounds.
M Chan-Yeung; H Chan; K S Tse; H Salari; S Lam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  84     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  762-8     Citation Subset:  AIM; IM    
Department of Rheumatology, Ichilov Hospital, Tel Aviv, Israel.
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MeSH Terms
Allergens / pharmacology
Asthma / etiology,  metabolism,  physiopathology*
Bronchi / drug effects,  metabolism,  physiopathology*
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid / analysis,  cytology
Histamine Release* / drug effects
Leukotrienes / secretion*
Middle Aged
Naphthols / pharmacology*
Occupational Diseases / physiopathology
Reg. No./Substance:
0/Allergens; 0/Leukotrienes; 0/Lignans; 0/Naphthols; 16462-65-0/plicatic acid

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