Document Detail

Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation.
MedLine Citation:
PMID:  6148254     Owner:  NLM     Status:  MEDLINE    
Microiontophoretic application of the histamine H2-receptor antagonist cimetidine selectively attenuated the histamine-induced, but not the gamma-aminobutyric acid (GABA)-induced, depression of serotoninergic cells recorded in the dorsal raphe nucleus of the rat. These data support the view that an H2-receptor mediates the effects of histamine on these serotoninergic neurons. We also now ascribe a previous report of GABA-like properties of cimetidine and metiamide to an impurity in the lots of these compounds used originally.
J M Lakoski; D W Gallager; G K Aghajanian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  103     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-20     Completed Date:  1984-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
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MeSH Terms
Cimetidine / pharmacology*
Histamine / pharmacology*
Histamine H2 Antagonists / pharmacology
Iontophoresis / methods
Muscimol / metabolism
Neurons / physiology*
Raphe Nuclei / physiology*
Rats, Inbred Strains
Serotonin / physiology*
gamma-Aminobutyric Acid / metabolism
Grant Support
Reg. No./Substance:
0/Histamine H2 Antagonists; 2763-96-4/Muscimol; 50-67-9/Serotonin; 51-45-6/Histamine; 51481-61-9/Cimetidine; 56-12-2/gamma-Aminobutyric Acid

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