Document Detail

Histamine-induced cyclic AMP accumulation in type-1 and type-2 astrocytes in primary culture.
MedLine Citation:
PMID:  1663048     Owner:  NLM     Status:  MEDLINE    
Histamine-induced cyclic AMP (cAMP) accumulation was studied in purified primary cultures of type-1 and type-2 astrocytes from neonatal rat brain. Histamine induced remarkable cAMP accumulation in type-1 astrocytes in a dose-dependent manner (EC50 = 1.2 x 10(-5) M, Emax = 1100% of control). In contrast, histamine had no significant effect on cAMP accumulation in type-2 astrocytes. Famotidine, an H2-antagonist, dose-dependently inhibited histamine-induced cAMP accumulation in type-1 astrocytes (Ki = 3 x 10(-8) M), but mepyramine (10(-6) M), an H1-antagonist, had no effect. Dimaprit and impromidine, H2-agonists, stimulated cAMP accumulation, but 2-pyridylethylamine, an H1-agonist, did not stimulate it nor augment the H2-agonist-induced cAMP accumulation. These results indicate that (1) histamine induces cAMP accumulation in type-1 astrocytes but not in type-2 astrocytes, and that (2) histamine-induced cAMP accumulation in type-1 astrocytes is mediated by H2-receptors without significant augmentation via H1-receptors.
A Kubo; H Fukui; N Inagaki; A Kanamura; H Wada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  208     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-25     Completed Date:  1992-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan.
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MeSH Terms
Astrocytes / cytology,  drug effects,  metabolism*
Cells, Cultured
Cyclic AMP / metabolism*
Famotidine / pharmacology
Histamine / pharmacology*
Pyrilamine / pharmacology
Rats, Inbred Strains
Receptors, Histamine H2 / physiology
Stimulation, Chemical
Reg. No./Substance:
0/Receptors, Histamine H2; 51-45-6/Histamine; 60-92-4/Cyclic AMP; 76824-35-6/Famotidine; 91-84-9/Pyrilamine

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