Document Detail

Histamine in foods: its possible role in non-allergic adverse reactions to ingestants.
MedLine Citation:
PMID:  3302658     Owner:  NLM     Status:  MEDLINE    
Histamine is well recognized as a product of both mast cells and basophils. Its release from these sources in IgE-mediated reactions unquestionably contributes to the allergic response. It is often stated that ingestion of foods rich in histamine can result in absorption of sufficient histamine to provoke signs and symptoms reminiscent of an allergic reaction. A review of literature relevant to this issue suggests that certain foods do indeed contain histamine as measured by current methodology. Further, histamine ingestion in excess of 36 to 250 mg may or may not result in a clinical response which includes abdominal complaints, feelings of warmth, flushing and headache. Taken together, this evidence supports the hypothesis that ingestion of large amounts of histamine-containing foods or foods which contain the histamine precursor, histidine, under some circumstances can result in adverse reactions.
M H Malone; D D Metcalfe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  New England and regional allergy proceedings     Volume:  7     ISSN:  0742-2814     ISO Abbreviation:  N Engl Reg Allergy Proc     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1987-09-09     Completed Date:  1987-09-09     Revised Date:  2007-06-14    
Medline Journal Info:
Nlm Unique ID:  8306562     Medline TA:  N Engl Reg Allergy Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
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MeSH Terms
Cheese / adverse effects
Food / adverse effects*
Histamine / adverse effects*,  metabolism
Imidazoles / urine
Meat / adverse effects
Vegetables / adverse effects
Wine / adverse effects
Reg. No./Substance:
0/Imidazoles; 2625-49-2/methylimidazoleacetic acid; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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