Document Detail

Histamine and gastric acid secretion. A review.
MedLine Citation:
PMID:  1645887     Owner:  NLM     Status:  MEDLINE    
Histamine was found to be a potent stimulus for acid secretion in 1920. It was then for about 20 years considered to be identical to the antral factor gastrin. It stimulates the parietal cells--the site of acid production--via an H2-receptor in a dynamic manner--that is, there is a continuous turnover of histamine at the receptor site. Cyclic AMP is formed by the receptor stimulation, but how this is coupled to the proton transport is unknown. It could even be possible that the main function of the histamine action is to initiate the drastic morphologic transformation of the parietal cells which occurs in connection with acid secretion. Possible sites for some acid inhibitors are elucidated.
K J Obrink
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  180     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-11     Completed Date:  1991-07-11     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  4-8     Citation Subset:  IM    
Dept. of Physiology and Medical Biophysics, Uppsala University, Sweden.
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MeSH Terms
Adenosine Triphosphatases / physiology
Cyclic AMP / physiology
Gastric Acid / secretion*
H(+)-K(+)-Exchanging ATPase
Histamine / physiology*
Parietal Cells, Gastric / secretion
Receptors, Histamine H2 / physiology
Reg. No./Substance:
0/Receptors, Histamine H2; 51-45-6/Histamine; 60-92-4/Cyclic AMP; EC 3.6.1.-/Adenosine Triphosphatases; EC ATPase

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