| Histamine and gastric acid secretion. A review. | |
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MedLine Citation:
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PMID: 1645887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histamine was found to be a potent stimulus for acid secretion in 1920. It was then for about 20 years considered to be identical to the antral factor gastrin. It stimulates the parietal cells--the site of acid production--via an H2-receptor in a dynamic manner--that is, there is a continuous turnover of histamine at the receptor site. Cyclic AMP is formed by the receptor stimulation, but how this is coupled to the proton transport is unknown. It could even be possible that the main function of the histamine action is to initiate the drastic morphologic transformation of the parietal cells which occurs in connection with acid secretion. Possible sites for some acid inhibitors are elucidated. |
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Authors:
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K J Obrink |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 180 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-07-11 Completed Date: 1991-07-11 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 4-8 Citation Subset: IM |
Affiliation:
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Dept. of Physiology and Medical Biophysics, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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physiology Cyclic AMP / physiology Gastric Acid / secretion* H(+)-K(+)-Exchanging ATPase Histamine / physiology* Humans Parietal Cells, Gastric / secretion Receptors, Histamine H2 / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Histamine H2; 51-45-6/Histamine; 60-92-4/Cyclic AMP; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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