| Histamine H2 receptor stimulation increases gastric emptying in monkeys. | |
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MedLine Citation:
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PMID: 2974243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of the specific H2 receptor agonist dimaprit on gastric emptying using a dye dilution technique in five chair-adapted rhesus monkeys to determine simultaneously gastric emptying and H+ secretion. Continuous subcutaneous injections of either saline alone or dimaprit (15, 30, 60, 120, and 240 nmol.kg-1.min-1) were given in random order on separate days. Both fractional emptying rate and H+ output were significantly increased by higher doses of dimaprit, with resulting twofold concurrent increase of intragastric H+ concentration. Because intragastric administration of H+ decreases gastric emptying and secretion, we evaluated the possibility that the stimulatory action of a histamine H2 agonist was underestimated when gastric pH was greater during control than after dimaprit. When exogenous HCl was added to the stomach to achieve H+ concentrations similar to those measured after dimaprit, both fractional emptying and H+ secretion were decreased twofold. When these "acidified control values" were used as a point of comparison, the stimulatory effect of dimaprit on both fractional emptying and gastric secretion was greater, suggesting that the stimulatory actions of dimaprit are underestimated if one does not take into account the differences in intragastric H+ concentrations. |
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Authors:
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A Dubois; D Nompleggi; D O Castell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 255 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G767-71 Citation Subset: IM |
Affiliation:
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Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dimaprit Gastric Acid / secretion* Gastric Emptying* / drug effects Gastric Juice / drug effects Macaca mulatta Male Receptors, Histamine H2 / drug effects, physiology* Reference Values Thiourea / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Histamine H2; 62-56-6/Thiourea; 65119-89-3/Dimaprit |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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