Document Detail

Histamine H1 antagonists and clinical characteristics of febrile seizures.
MedLine Citation:
PMID:  22505826     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The purpose of this study was to determine whether seizure susceptibility due to antihistamines is provoked in patients with febrile seizures.
METHODS: The current descriptive study was carried out from April 2009 to February 2011 in 250 infants and children who visited the Madinah Maternity and Children's Hospital as a result of febrile convulsions. They were divided into two groups according to administration of antihistamines at the onset of fever.
RESULTS: Detailed clinical manifestations were compared between patients with and without administration of antihistamines. The time from fever detection to seizure onset was significantly shorter in the antihistamine group than that in the nonantihistamine group, and the duration of seizures was significantly longer in the antihistamine group than in the nonantihistamine group. No significant difference was found in time from fever detection to seizure onset or seizure duration between patients who received a first-generation antihistamine and those who received a second-generation antihistamine.
CONCLUSION: Due to their central nervous system effects, H1 antagonists should not be administered to patients with febrile seizures and epilepsy. Caution should be exercised regarding the use of histamine H1 antagonists in young infants, because these drugs could potentially disturb the anticonvulsive central histaminergic system.
Mohammed A Zolaly
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Publication Detail:
Type:  Journal Article     Date:  2012-03-20
Journal Detail:
Title:  International journal of general medicine     Volume:  5     ISSN:  1178-7074     ISO Abbreviation:  Int J Gen Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101515487     Medline TA:  Int J Gen Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  -    
Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.
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