Document Detail

Histamine H1- and H2-receptors in the cat and their roles during alveolar hypoxia.
MedLine Citation:
PMID:  882726     Owner:  NLM     Status:  MEDLINE    
We sought to define the roles of H1-and H2-receptors in the cat and to evaluate the roles of these receptors during alveolar hypoxia. In pentobarbital anesthetized cats, we found that histamine infusion (1.1 microgram/kg/min for 3 min) increased cardiac output and decreased pulmonary and systemic vascular resistances. However, when cardiac output was held constant, histamine infusion induced pulmonary vasoconstriction. Histamine infusions after H1-and H2-receptor blockade (chlorpheniramine and metiamde, respctively) indicated that H2-receptors mediated systemic vasodilatation. In the lung, H1-receptors mediated vasoconstriction, and H2-receptors mediated vasodilatation. Hypoxia (10% O2) caused large increases in pulmonary vascular resistance which were not blocked by H1-, H2-, or combined H1- and H2-receptor blockade. In the intact cat, histamine does not appear to mediate hypoxic pulmonary hypertension.
E A Hoffman; M L Munroe; A Tucker; J T Reeves
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  29     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  255-64     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Cardiac Output
Chlorpheniramine / pharmacology
Heart Rate
Histamine / pharmacology
Lung / blood supply*
Metiamide / pharmacology
Pulmonary Alveoli
Receptors, Histamine / physiology*
Receptors, Histamine H1 / physiology*
Receptors, Histamine H2 / physiology*
Vascular Resistance
Vasomotor System / physiology*
Reg. No./Substance:
0/Receptors, Histamine; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 132-22-9/Chlorpheniramine; 34839-70-8/Metiamide; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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