Document Detail

Histamine and 5-hydroxytryptamine in human scar tissue.
MedLine Citation:
PMID:  3994269     Owner:  NLM     Status:  MEDLINE    
Patients with unstable scars in some areas of the body complain of local itchiness and pain, which may be caused by histamine and serotonin. Therefore, I measured these substances in scar tissue in various conditions taken at the time of operation. The histamine value was determined by the amount of carbon dioxide produced in histidine decarboxylase activity (HDCA); the measurement of 5-hydroxytryptamine (5-HT) was done by the Ninhydrin method. High values of HDCA were usually found in skin flaps and scar tissue around pressure sores. 5-HT activity reached a higher level in unstable scars than in stable scars.
T Nara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  14     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-7     Citation Subset:  IM    
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MeSH Terms
Carboxy-Lyases / analysis*
Child, Preschool
Cicatrix / enzymology,  metabolism*,  pathology
Histamine / analysis*
Histidine Decarboxylase / analysis*
Middle Aged
Serotonin / analysis*
Skin / enzymology
Time Factors
Reg. No./Substance:
50-67-9/Serotonin; 51-45-6/Histamine; EC 4.1.1.-/Carboxy-Lyases; EC Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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