Document Detail


Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. II. Isolation, characterization and structural elucidation.
MedLine Citation:
PMID:  7509787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hispidospermidin (1) is a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. Its structure (C25H47N3O) has been elucidated as a cage compound with a trimethylspermidine side chain based on various NMR studies, including 1H-1H COSY, 13C-1H COSY, HOHAHA, HMBC, COLOC and long range J C-H resolved 2D spectroscopy. The absolute configuration of 1 has been elucidated by modified Mosher's method on the (R)- and (S)-MTPA amides of a derivative of 1.
Authors:
T Ohtsuka; Y Itezono; N Nakayama; A Sakai; N Shimma; K Yokose; H Seto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  47     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  6-15     Citation Subset:  IM    
Affiliation:
Nippon Roche Research Center, Kamakura, Japan.
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MeSH Terms
Descriptor/Qualifier:
Chaetomium / metabolism*
Polycyclic Compounds / chemistry*,  isolation & purification*
Spermidine / analogs & derivatives*,  chemistry,  isolation & purification
Stereoisomerism
Structure-Activity Relationship
Type C Phospholipases / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Polycyclic Compounds; 0/hispidospermidin; 124-20-9/Spermidine; EC 3.1.4.-/Type C Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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