| Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. II. Isolation, characterization and structural elucidation. | |
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MedLine Citation:
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PMID: 7509787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hispidospermidin (1) is a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. Its structure (C25H47N3O) has been elucidated as a cage compound with a trimethylspermidine side chain based on various NMR studies, including 1H-1H COSY, 13C-1H COSY, HOHAHA, HMBC, COLOC and long range J C-H resolved 2D spectroscopy. The absolute configuration of 1 has been elucidated by modified Mosher's method on the (R)- and (S)-MTPA amides of a derivative of 1. |
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Authors:
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T Ohtsuka; Y Itezono; N Nakayama; A Sakai; N Shimma; K Yokose; H Seto |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 47 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-04-07 Completed Date: 1994-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 6-15 Citation Subset: IM |
Affiliation:
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Nippon Roche Research Center, Kamakura, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chaetomium
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metabolism* Polycyclic Compounds / chemistry*, isolation & purification* Spermidine / analogs & derivatives*, chemistry, isolation & purification Stereoisomerism Structure-Activity Relationship Type C Phospholipases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Polycyclic Compounds; 0/hispidospermidin; 124-20-9/Spermidine; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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