| Hirudin therapy during thrombolysis for venous thrombosis in heparin-induced thrombocytopenia. | |
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MedLine Citation:
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PMID: 11213236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin-induced thrombocytopenia (HIT) is the most common drug-related thrombocytopenia. Thromboembolic complications occur in approximately 50% of patients with HIT and result in limb amputation and death in up to 20% and 30% respectively. Because patients with a history of HIT may require future intravenous anticoagulation but have a high-risk of thromboembolism if re-challenged with heparin, alternative therapies are necessary when further anticoagulation is indicated. The use of direct thrombin inhibitors in HIT patients who also require thrombolytic therapy offers unique challenges to anticoagulant monitoring and safety. We present a case of progressive ileofemoral deep venous thrombosis in a patient with a history of HIT in order to review the combined use of hirudin and thrombolysis in this setting. |
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Authors:
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M P Reilly; R Weiss; A Askenase; C Tuite; M Soulen; E R Mohler |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 5 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2000 |
Date Detail:
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Created Date: 2001-02-12 Completed Date: 2001-06-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 239-42 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Heparin / adverse effects* Hirudin Therapy* Hirudins / analogs & derivatives* Humans Male Middle Aged Phlebography Recombinant Proteins / therapeutic use* Thrombocytopenia / chemically induced*, radiography Thrombolytic Therapy / methods* Treatment Outcome Venous Thrombosis / drug therapy*, etiology, radiography |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Hirudins; 0/Recombinant Proteins; 120993-53-5/desirudin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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