Document Detail

MedLine Citation:
PMID:  18081798     Owner:  NLM     Status:  MEDLINE    
Hirsutism is defined as the excessive growth of terminal hair on the face and body of a female in a typical male pattern distribution. Hirsutism is a common clinical problem in women and the treatment depends on the cause of hirsutism. Untreated hirsutism can be associated with considerable loss of self-esteem and psychological morbidity. Hyperandrogenemia is the key trigger for excess hair growth. Polycystic ovary syndrome and idiopathic hirsutism are the most common cause of hirsutism. As with all medical problems, investigation begins with a careful history, examination and then investigation directed at the possible cause. A raised serum testosterone level of > 150 ng/dl (5.2 nmol/l) should prompt further investigations to exclude an underlying androgen-secreting tumour. The treatment of hirsutism is most effective using combination therapy, including lifestyle therapies, androgen suppression, peripheral androgen blockage and cosmetic treatments. Women should be warned not to expect improvement or at least 3-6 months after therapy is begun and lifelong therapy may be needed to prevent recurrence. The current review discusses definition, pathogenesis, differential diagnosis, diagnostic strategies, management, guidelines and the authors' recommendations about hirsutism.
A Mofid; S A Seyyed Alinaghi; S Zandieh; T Yazdani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-12-11
Journal Detail:
Title:  International journal of clinical practice     Volume:  62     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-43     Citation Subset:  IM    
Department of Internal Medicine, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran.
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MeSH Terms
Diagnosis, Differential
Eflornithine / therapeutic use*
Enzyme Inhibitors / therapeutic use
Hair Removal
Hirsutism* / diagnosis,  etiology,  therapy
Hypertrichosis / diagnosis
Laser Therapy
Life Style
Polycystic Ovary Syndrome / complications,  therapy
Practice Guidelines as Topic
Testosterone / metabolism
Treatment Outcome
Weight Loss
Reg. No./Substance:
0/Enzyme Inhibitors; 58-22-0/Testosterone; 70052-12-9/Eflornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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