| Hippuric acid and ortho-cresol as biological indicators of occupational exposure to toluene. | |
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MedLine Citation:
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PMID: 3591803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Industrial exposure to toluene was studied in a group of 18 subjects working in a printing plant, exposed only to this solvent. Environmental monitoring was carried out using personal samplers for the whole work-shift. Urine samples were collected for the determination of hippuric acid and ortho(o)-cresol before toluene exposure, at the end of the work-shift, and 5, 9, and 17 h after the end of the work-shift. The values of two metabolites in all the urinary samples were corrected for g creatinine and specific gravity (1.024). Toluene time weighted average (TWA) concentrations ranged from 51 to 221 mg/m3 (7-h samples; two samplings lasting 3.5 h each). Urinary hippuric acid and o-cresol values at the end of the work-shift were significantly higher than the prework-shift values. Both hippuricuria and o-cresoluria end-of-work-shift values, corrected for creatinine and specific gravity, were significantly related to the mean daily environmental concentration of toluene, the correlation being weaker for o-cresol. Correlation coefficients were 0.88 and 0.84 for hippuric acid and 0.63 and 0.62 for o-cresol after correction for creatinine and specific gravity, respectively. No significant relationship was observed between environmental exposure and the values of the two urinary metabolites 5, 9, and 17 h after the end of the work-shift. Extrapolated values from the linear regression analysis at 375 mg/m3 were in good agreement with the biological exposure index (BEI) suggested by ACGIH for hippuric acid.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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E De Rosa; G B Bartolucci; M Sigon; R Callegaro; L Perbellini; F Brugnone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of industrial medicine Volume: 11 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-07-16 Completed Date: 1987-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 529-37 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cresols
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metabolism,
urine* Hippurates / metabolism, urine* Humans Male Monitoring, Physiologic Occupational Diseases / chemically induced*, diagnosis, urine Toluene / metabolism, poisoning* |
| Chemical | |
Reg. No./Substance:
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0/Cresols; 0/Hippurates; 108-88-3/Toluene; 495-69-2/hippuric acid; 95-48-7/2-cresol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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