| Hippuric acid and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in serum and urine. Analytical approaches and clinical relevance in kidney diseases. | |
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MedLine Citation:
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PMID: 2329153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hippuric acid (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (FA) were determined in serum, plasma, ultrafiltrate and urine by gas chromatography (GC), high-performance liquid chromatography and GC with mass-selective detection, and the methods were compared. As determined by affinity chromatography and analysis of serum and ultrafiltrate, 0.5% of FA in serum occurs free and 99.5% is bound to albumin. In haemodialysed patients with chronic renal failure, the plasma levels of HA and FA are elevated in comparison with normal controls and hospital patients without kidney diseases: HA, 11.1 +/- 5.7 mg/dl (n = 86); FA, 1.9 +/- 1.2 mg/dl (n = 86). Gradual increases in HA in serum, depending on the creatinine concentrations, are found in non-dialysed patients with chronic renal failure. By haemodialysis and haemofiltration the HA levels are lowered (53-66 and 30-36%, respectively), whereas FA is not dialysable. |
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Authors:
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H M Liebich; J I Bubeck; A Pickert; G Wahl; A Scheiter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatography Volume: 500 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-05-31 Completed Date: 1990-05-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 615-27 Citation Subset: IM |
Affiliation:
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Medizinische Universitätsklinik, Tübingen, F.R.G. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gas
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methods Chromatography, High Pressure Liquid / methods* Furans / blood*, urine Hemofiltration Hippurates / blood*, urine Humans Kidney Failure, Chronic / blood*, therapy, urine Propionates / blood* Propionic Acids / blood*, urine Reference Values Renal Dialysis |
| Chemical | |
Reg. No./Substance:
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0/Furans; 0/Hippurates; 0/Propionates; 0/Propionic Acids; 495-69-2/hippuric acid; 86879-39-2/3-carboxy-4-methyl-5-propyl-2-furanpropionic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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