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Hippocampal volumes and cognitive functions in adult alcoholic patients with adolescent-onset.
MedLine Citation:
PMID:  23063480     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated hippocampal volumes and cognitive functions in adult alcoholic patients with adolescent- or late-onset alcohol use. Twenty-one male alcohol dependent inpatients and 13 healthy male controls were enrolled in this study. Cranial magnetic resonance imaging to measure hippocampal volumes and neuropsychological tests were performed in week 4 of abstinence in the patients and controls. The patients were divided into two subgroups (adolescent- and late-onset subgroups) according to the onset age of alcohol use. Alcoholic patients in general had significantly smaller right hippocampal volumes than the healthy controls. Patients' immediate memory, attention, acquisition and working memory subtest scores were inferior to those of the controls. The right hippocampus was significantly smaller in adult alcoholic patients with adolescent-onset use compared to the controls and the late-onset group. There was no significant correlation between neuropsychological test scores and hippocampal volumes. Our results suggest that hippocampal volume loss might be a feature of adolescent-onset alcoholic patients rather than of late-onset ones.
Authors:
Saliha Ozsoy; Ahmet Candan Durak; Ertugrul Esel
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  -     ISSN:  1873-6823     ISO Abbreviation:  Alcohol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Erciyes University School of Medicine, Department of Psychiatry, Talas Road, 38039 Kayseri, Turkey. Electronic address: sozsoy@erciyes.edu.tr.
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