Document Detail

Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms.
MedLine Citation:
PMID:  21262043     Owner:  NLM     Status:  In-Data-Review    
It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder.
Sarah Whittle; Marie B H Yap; Lisa Sheeber; Paul Dudgeon; Murat Yücel; Christos Pantelis; Julian G Simmons; Nicholas B Allen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development and psychopathology     Volume:  23     ISSN:  1469-2198     ISO Abbreviation:  Dev. Psychopathol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910645     Medline TA:  Dev Psychopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-29     Citation Subset:  IM    
University of Melbourne.
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