Document Detail

Hippocampal volume measurement in patients with Ménière's disease: a pilot study.
MedLine Citation:
PMID:  17851902     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: No signs of chronic stress as in hippocampal atrophy were present in patients with Ménière's disease. OBJECTIVE: To evaluate the effect of chronic stress (allostatic load) by measuring hippocampal volume in patients with Ménière's disease. SUBJECTS AND METHODS: Ten patients with Meniere's disease and 10 healthy controls were evaluated for absolute and relative hippocampal volumes measured on MRI scans, saliva cortisol levels and frequency of daily stressors. The study was performed in a prospective, controlled setting with two raters who were blinded as to subject identity. RESULTS: Saliva cortisol levels and presence of daily stressor scores were similar in both groups. The first rater measured mean hippocampal volumes of 2.80 +/- 0.36 cm3 vs 3.15 +/- 0.52 cm3 (right) and 2.49 +/- 0.32 cm3 vs 3.06 +/- 0.46 cm3 (left), for the Ménière's disease and control group, respectively. The second rater measured 3.44 +/- 0.35 cm3 vs 3.60 +/- 0.52 cm3 (right) and 3.00 +/- 0.40 cm3 vs 3.42 +/- 0.45 cm3 (left), respectively. The volume of the left hippocampus was significantly smaller in patients with Ménière's disease compared with the controls for both raters (p < 0.05) and the right hippocampal volume was not different between the two groups. With correction for variation in head size (partial brain and partial intracranial volume) no significant differences in relative hippocampal volumes were observed between patients with Ménière's disease and the control group.
Nynke Van Cruijsen; Wilma M Hiemstra; Linda C Meiners; Hero P Wit; Frans W J Albers
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  127     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1018-23     Citation Subset:  IM    
Department of Otorhinolaryngology, University Medical Center Groningen, Groningen, The Netherlands.
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MeSH Terms
Hippocampus / pathology*
Hydrocortisone / metabolism
Magnetic Resonance Imaging / methods*
Meniere Disease / diagnosis*,  metabolism
Middle Aged
Pilot Projects
Prospective Studies
Reproducibility of Results
Saliva / chemistry
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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