| Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage. | |
| | |
MedLine Citation:
|
PMID: 18238850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: The individual extent of structural brain tissue changes in patients with alcohol dependence is influenced by genetic factors, gender, age and possibly a dose/duration-effect. Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism. METHODS: We included 52 patients with alcohol dependence and divided them according to their preferred type of beverage consumption (beer, wine, and spirits). Hippocampal volumes were determined using volumetric high-resolution MR imaging. RESULTS: There was a significant difference in hippocampal volumes between patients consuming different beverages (ANOVA: F = 7.454; df = 2; P = 0.0015) with the smallest volumes in the wine group, followed by the spirits group. Furthermore, patients with a preferred spirits consumption showed significantly higher plasma homocysteine levels (ANOVA: F = 3.39; df = 2; P = 0.042). Linear regression analyses revealed an association of homocysteine and hippocampal volume only in the group of patients preferring spirits (R(2) = 0.364; P = 0.008). CONCLUSIONS: Homocysteine-mediated excitotoxicity may be an important pathophysiological mechanism in ethanol-related brain damage, particularly in patients consuming wine and spirits. The extent of brain atrophy in beer consuming patients seems to be more moderate. |
| | |
Authors:
|
Julia Wilhelm; Helge Frieling; Thomas Hillemacher; Detlef Degner; Johannes Kornhuber; Stefan Bleich |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-31 |
Journal Detail:
|
Title: Alcohol and alcoholism (Oxford, Oxfordshire) Volume: 43 ISSN: 1464-3502 ISO Abbreviation: Alcohol Alcohol. Publication Date: 2008 May-Jun |
Date Detail:
|
Created Date: 2008-05-05 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8310684 Medline TA: Alcohol Alcohol Country: England |
Other Details:
|
Languages: eng Pagination: 296-9 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany. julia.wilhelm@uk-erlangen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Alcoholic Beverages / adverse effects* Alcoholism / epidemiology, pathology* Beer / adverse effects Female Hippocampus / drug effects*, pathology* Humans Male Middle Aged Organ Size Wine / adverse effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells.
Next Document: A review of the literature on the cognitive effects of alcohol hangover.