Document Detail

Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage.
MedLine Citation:
PMID:  18238850     Owner:  NLM     Status:  MEDLINE    
AIMS: The individual extent of structural brain tissue changes in patients with alcohol dependence is influenced by genetic factors, gender, age and possibly a dose/duration-effect. Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism. METHODS: We included 52 patients with alcohol dependence and divided them according to their preferred type of beverage consumption (beer, wine, and spirits). Hippocampal volumes were determined using volumetric high-resolution MR imaging. RESULTS: There was a significant difference in hippocampal volumes between patients consuming different beverages (ANOVA: F = 7.454; df = 2; P = 0.0015) with the smallest volumes in the wine group, followed by the spirits group. Furthermore, patients with a preferred spirits consumption showed significantly higher plasma homocysteine levels (ANOVA: F = 3.39; df = 2; P = 0.042). Linear regression analyses revealed an association of homocysteine and hippocampal volume only in the group of patients preferring spirits (R(2) = 0.364; P = 0.008). CONCLUSIONS: Homocysteine-mediated excitotoxicity may be an important pathophysiological mechanism in ethanol-related brain damage, particularly in patients consuming wine and spirits. The extent of brain atrophy in beer consuming patients seems to be more moderate.
Julia Wilhelm; Helge Frieling; Thomas Hillemacher; Detlef Degner; Johannes Kornhuber; Stefan Bleich
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-31
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  43     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany.
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MeSH Terms
Alcoholic Beverages / adverse effects*
Alcoholism / epidemiology,  pathology*
Beer / adverse effects
Hippocampus / drug effects*,  pathology*
Middle Aged
Organ Size
Wine / adverse effects

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