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Hippocampal sclerosis and a second focal lesion-How often is it ipsilateral?
MedLine Citation:
PMID:  21426330     Owner:  NLM     Status:  Publisher    
Purpose:  Hippocampal sclerosis (HS) is the most common pathologic finding in intractable temporal lobe epilepsy (TLE). In many patients, HS is accompanied by an extrahippocampal lesion (EHL). We sought to assess the lobar distribution and side of EHLs in relation to HS in a large consecutive series of patients presenting to our epilepsy surgery program. Methods:  The inclusion criterion was the presence of both definite HS and an unequivocal EHL on magnetic resonance imaging (MRI) studies in patients evaluated for potential epilepsy surgery at our tertiary epilepsy center. Key Findings:  Fifty-eight patients were identified over a 7-year period. This represented about one-third of all patients with HS. The mean age was 32 years (SD 18.4), and the mean age of seizure onset 13 years (SD 16.4). Fifty-four percent of the EHLs could be classified as acquired and 36% as developmental. In 98% of patients HS was found on the same side as EHL. Significance:  Our findings support the hypothesis that HS may be a secondary event from seizures generated initially by another focal lesion. However, HS and EHL may also originate from the same insult to the brain.
Paul A M Hofman; Gregory Fitt; L Anne Mitchell; Graeme D Jackson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.
Department of Radiology, University Hospital Maastricht, Maastricht, The Netherlands Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia Department of Radiology, Austin Health, Melbourne, Victoria, Australia Department of Medicine, University of Melbourne, Parkville, Victoria, Australia Department of Radiology, University of Melbourne, Parkville, Victoria, Australia.
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