Document Detail

Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study.
MedLine Citation:
PMID:  12601713     Owner:  NLM     Status:  MEDLINE    
Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure-free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy.
Darren Fuerst; Jagdish Shah; Aashit Shah; Craig Watson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  53     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-25     Completed Date:  2003-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-6     Citation Subset:  IM    
Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
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MeSH Terms
Chi-Square Distribution
Disease Progression
Epilepsy, Temporal Lobe / pathology
Hippocampus / pathology*
Longitudinal Studies
Magnetic Resonance Imaging / methods*,  statistics & numerical data
Middle Aged

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