| Hippocampal prosaposin changes during stress: a glucocorticoid-independent event. | |
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MedLine Citation:
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PMID: 15132426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies indicate that stress can produce remarkable effects on neurotrophic factors. In this regard, hippocampus is the most interesting structure of the brain because of its broad involvement in behavioral and neuroendocrine phenomena. In the present study, we investigated the effect of stress on hippocampal prosaposin, which is known to act as a neurotrophic and neuroprotective factor. Rats subjected to restraint stress (120 min) had a significant and transient reduction of hippocampal, but not hypothalamic, prosaposin full-length protein. Indeed, when this stressful stimulus was applied daily for 3 days, no differences were detected in comparison with naive rats. To investigate the role of glucocorticoids in the stress-induced decrease in hippocampal prosaposin, adrenalectomized and corticosterone-treated rats were studied. The results indicate that adrenalectomized rats behave as intact animals. This finding indicates that the absence of endogenous corticosterone does not prevent a decrease in hippocampal prosaposin. When an increase of corticosterone was achieved through exogenous administration, hippocampal prosaposin concentrations were unchanged in comparison with vehicle-injected (sesame oil) rats. These results led to the conclusion that stress, not via an increase of glucocorticoid hormone, transiently reduces hippocampal prosaposin levels. This phenomenon is followed by rapid recovery of the neurotrophin level, even when the stress stimulus persists. |
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Authors:
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Sergio Scaccianoce; Vincenzo Mattei; Paola Del Bianco; Chiara Gizzi; Maurizio Sorice; Masao Hiraiwa; Roberta Misasi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hippocampus Volume: 14 ISSN: 1050-9631 ISO Abbreviation: Hippocampus Publication Date: 2004 |
Date Detail:
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Created Date: 2004-05-10 Completed Date: 2004-07-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: United States |
Other Details:
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Languages: eng Pagination: 275-80 Citation Subset: IM |
Affiliation:
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Dipartimento di Fisiologia Umana e Farmacologia, Vittorio Erspamer, Roma, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Animals Corticosterone / pharmacology, physiology Down-Regulation / drug effects, physiology* Glucocorticoids / pharmacology, physiology* Glycoproteins / metabolism* Hippocampus / drug effects, metabolism*, physiopathology Hypothalamus / metabolism Male Nerve Growth Factors / pharmacology* Rats Rats, Wistar Recovery of Function / drug effects, physiology Saposins Stress, Physiological / metabolism*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Glycoproteins; 0/Nerve Growth Factors; 0/Psap protein, rat; 0/Saposins; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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